With the "standard cost" mileage allowance rising to 34.5 cents per mile, it's time to convert all cars and pickup trucks from "actual" to standard cost. Actual cost, which multiplies itemized total vehicle expenses for gas, repairs, insurance, and depreciation by percentage of business use would probably average 30% less at just $16,000 ($6,000 depreciation -- the first year maximum is $3,150 -- plus about $10,000 in other expenses).
The IRS keeps expanding the home office deduction. The space must be used regularly and exclusively for a business purpose, but you can take the deduction even if you commute to an outside place of business every day.